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The normal process of follow up to the Notice is that NexMed has 90 days from the date of the Notice to respond to Health Canada, followed by the Health Canada 45 day screening process in the Regulatory Project Management group and then a 150 day review cycle by the NDS reviewers.
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Methods: Published literature on this topic was identified by using MEDLINE (1966 to May 2007), EMBASE (1980 to week 22 of 2007), Cochrane Central Register of Controlled Trials (second quarter of 2007), PsycINFO (1985 to June 2007), AMED (1985 to June 2007), and SCOPUS (2006). The literature search was updated by searching for articles in MEDLINE and EMBASE published between May 2007 and April 2009. Searches were limited to English-language publications. This guideline grades the evidence and recommendations by using the American College of Physicians' clinical practice guidelines grading system.
One such research area has involved the use of the angiogenic growth factor and endothelial cell mitogen, vascular endothelial growth factor (VEGF). This is produced by vascular smooth muscle, endothelial, and inflammatory cells. VEGF increases the production of nitric oxide, which improves endothelial function and blood flow in chronic ischemic disorders.
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